Inhibitors of c-fms kinase

Details Inhibitors of c-fms kinase Inhibitors of c-fms kinase

C - Chemistry, Metallurgy

07

D

C07D 233/90 (2006.01) A61K 31/4172 (2006.01) A61K 31/437 (2006.01) A61K 31/5377 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2650057

The invention is directed to compounds of Formula (I): wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula (I), are also provided.

L'invention concerne des composés de formule (I), dans laquelle Z, X, J, R2 et W sont tels que définis dans la description, ainsi que des solvates, des hydrates, des tautomères et des sels pharmaceutiquement acceptables de ces composés, qui inhibent les tyrosine kinases de protéines, en particulier la kinase de c-fms. L'invention concerne également des procédés de traitement de maladies auto-immunes et de maladies à composante inflammatoire ; de traitement de métastases de cancer de l'ovaire, de l'utérus, du sein, de la prostate, du poumon, du côlon, de l'estomac, de la leucémie à tricholeucocytes ; et de traitement de la douleur, y compris la douleur squelettique due à une métastase tumorale ou à l'ostéoarthrite, ou la douleur viscérale, inflammatoire et neurogène ; ainsi que de l'ostéoporose, la maladie de Paget et d'autres maladies dans lesquelles la résorption osseuse médie une morbidité, y compris la polyarthrite rhumatoïde et d'autre formes d'arthrite inflammatoire, l'ostéoarthrite, l'échec de la pose de prothèse, le sarcome ostéolytique, le myélome et les métastases tumorales à l'os en utilisant les composés de formule (I).

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