C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/04 (2006.01) A61K 31/4418 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 213/74 (2006.01) C07D 239/42 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2441733
The present invention provide a compound of formula I or II:or a pharmaceutically acceptable derivative thereof, wherein R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian proteinkinase involved cell proliferation, cell death and response to extracellular stimuli; and Src- family kinases, especially Src and Lck kinases. These compounds are also inhibitors of GSK3 and CDK2 kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
La présente invention concerne un composé de la formule I ou II où R¿1?, R¿2?, R¿3?, et R¿4? ont la définition donnée dans la description, ou un de leurs dérivés pharmaceutiquement tolérables. Ces composés sont des inhibiteurs de la protéine-kinase, notamment des inhibiteurs de la JNK, une protéinekinase de mammifère impliquée dans la prolifération des cellules, la mort des cellules et la réponse aux stimulus extracellulaires; et des kinases de la famille Src, notamment des kinases Src et Lck. Ces composés sont également des inhibiteurs des kinases GSK3 et CDK2. L'invention concerne également les procédés de production de ces inhibiteurs. L'invention concerne enfin des compositions pharmaceutiques contenant les inhibiteurs de l'invention et les procédés d'utilisation de ces compositions dans le traitement et la prévention de différents troubles.
Bethiel Randy S.
Cochran John
Moon Young-Choon
Nanthakumar Suganthini
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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