Inhibitors of cytosolic phospholipase a2

Details Inhibitors of cytosolic phospholipase a2 Inhibitors of cytosolic phospholipase a2

C - Chemistry, Metallurgy

07

D

C07D 209/14 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 307/00 (2006.01) C07D 317/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 487/08 (2006.01) C07D 491/08 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2469138

This invention provides substituted indole compounds of the general formula: (I) and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

L'invention concerne des composés d'indole substitués représentés par la formule générale (I). L'invention concerne également des formes salines, de ces composés, acceptables sur le plan pharmaceutique, et des procédés d'utilisation desdits composés en tant qu'inhibiteurs de l'activité de diverses enzymes phospholipases, notamment les enzymes phospholipases A<sb>2</sb>. Les composés de l'invention cont également utilisé dans le traitement médical, la prévention et l'inhibition de douleurs et d'inflammations.

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