Inhibitors of diacylglycerol acyltransferase

Details Inhibitors of diacylglycerol acyltransferase Inhibitors of diacylglycerol acyltransferase

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) C07D 401/04 (2006.01) C07D 403/14 (2006.01) C07D 407/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 471/10 (2006.01) C07D 487/08 (2006.01) C07D 493/10 (2006.01)

Patent

CA 2743497

The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase ("DGAT") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown with this abstract. Image

La présente invention concerne de nouveaux composés hétérocycliques en tant qu'inhibiteurs de diacylglycérol acyltransférase (« DGAT »), des compositions pharmaceutiques comprenant les composés hétérocycliques et l'utilisation des composés pour traiter ou prévenir une maladie cardiovasculaire, un trouble métabolique, l'obésité ou un trouble associé à l'obésité, le diabète, la dyslipidémie, une complication diabétique, une tolérance au glucose altérée ou une glycémie à jeun altérée. Un composé illustratif de l'invention est décrit ci-dessous :

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