Inhibitors of histone deacetylase

Details Inhibitors of histone deacetylase Inhibitors of histone deacetylase

C - Chemistry, Metallurgy

07

D

C07D 333/20 (2006.01) A61K 31/167 (2006.01) A61K 31/381 (2006.01) A61K 31/415 (2006.01) A61K 31/4436 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07C 237/42 (2006.01) C07D 231/40 (2006.01) C07D 295/145 (2006.01) C07D 401/06 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2642813

The present invention relates to a novel class of compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.

La présente invention concerne une nouvelle classe de composés. Ces composés sont capables d'inhiber l'histone désacétylase et ils peuvent être utilisés pour induire sélectivement la différenciation terminale et pour stopper la croissance cellulaire et/ou l'apoptose de cellules néoplasiques, inhibant ainsi la prolifération de ces cellules. Les composés de la présente invention sont donc utiles pour traiter un patient présentant une tumeur caractérisée par la prolifération de cellules néoplasiques. Les composés de l'invention peuvent aussi avoir une utilité dans la prévention et le traitement de maladies médiées par la TRX, par exemple des maladies auto-immunes, allergiques et inflammatoires, et dans la prévention et/ou le traitement de maladies du système nerveux central (SNC), par exemple des maladies neurodégénératives. L'invention concerne en outre des compositions pharmaceutiques comprenant les composés de l'invention, ainsi que des schémas posologiques sûrs de ces compositions pharmaceutiques, qui sont faciles à respecter et qui donnent une quantité thérapeutiquement efficace de ces composés in vivo.

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