C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/32 (2006.01) A61K 31/277 (2006.01) A61K 31/421 (2006.01) C07C 275/40 (2006.01)
Patent
CA 2367017
The present invention relates to compounds of formula (A) which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
L'invention concerne des composés inhibant l'inosine-5'-monophosphate déshydrogénase (IMPDH). Elle concerne également des compositions pharmaceutiques contenant ces composés. Les composés et compositions pharmaceutiques de l'invention sont notamment conçus pour inhiber l'activité de l'enzyme IMPDH, et, en conséquence, constituent des agents thérapeutiques avantageux dans des processus induits par IMPDH. L'invention concerne enfin des méthodes d'inhibition de l'activité de IMPDH, à l'aide des composés de l'invention et de composés voisins.
Badia Michael
Bethiel Scott
Ronkin Steven
Saunders Jeffrey
Stamos Dean
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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