C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 35/00 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2698256
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
L'invention concerne des composés qui inhibent les quatre kinases JAK de mammifères connues (JAK1, JAK2, JAK3 et TYK2) et PDK1. L'invention concerne également des compositions contenant ces composés inhibiteurs, ainsi que des méthodes d'inhibition de l'activité de JAK1, JAK2, JAK3 TYK2 et PDK1 consistant à administrer ledit composé à un patient nécessitant un traitement contre un cancer ou des troubles myéloprolifératifs.
Altman Michael
Childers Matthew
Katcher Matthew
Kozina Ekaterina
Northrup Alan
Gowling Lafleur Henderson Llp
Merck Sharp & Dohme Corp.
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