C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/04 (2006.01) A61K 31/422 (2006.01) A61K 31/423 (2006.01) A61K 31/424 (2006.01) C07C 45/61 (2006.01) C07C 269/06 (2006.01) C07D 261/20 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 487/08 (2006.01) C07D 498/10 (2006.01)
Patent
CA 2537185
The present invention relates to isoxazoline derivatives of structure (I), which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula I.
La présente invention concerne des dérivés d'isoxazoline pouvant être utilisés comme inhibiteurs sélectifs de la phosphodiestérase (PDE) de type IV. Les composés décrits dans la présente invention peuvent notamment être utiles pour traiter le sida, l'asthme, l'arthrite, la bronchite, la maladie obstructive respiratoire chronique (COPD), le psoriasis, la rhinite allergique, l'état de choc, la dermatite atopique, la maladie de Crohn, le syndrome respiratoire aigu sévère (SRAS), le granulome éosinophile, la conjonctivite allergique, l'arthrose, la rectocolite hémorragique et d'autres maladies inflammatoires chez un patient, notamment chez l'homme. La présente invention concerne également des procédés pour la préparation des composés décrits, ainsi que des compositions pharmaceutiques les contenant et leur utilisation comme inhibiteurs de la phosphodiestérase (PDE) de type IV.
Balachandran Sarala
Dastidar Sunanda G.
Gupta Nidhi
Kukreja Gagan
Palle Venkata P.
Dimock Stratton Llp
Ranbaxy Laboratories Limited
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