A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/185
A61K 47/00 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/70 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01)
Patent
CA 1267091
A B S T R A C T The invention relates to a process for the preparation of colour and pH stabilized aqueous parenteral pharmaceutical compositions comprising an antibacterial aminoglycoside comprising a pyranose ring being unsaturated between positions 4' and 5' and substituted with an aminoalkyl group at position 5', preferably sisomicine, netylmicine or 5-epi-sisomicine or the parenterally acceptable salts thereof. According to the process of the invention the active ingredient is dissolved in water, the pH of the solution is adjusted to 7,3 - 7,4, an antioxidant is added to the solution, nitrogen gas is bubbled through the solution after sterile filtration and the solution thus obtained is filled into ampoules.
503435
Jaray Miklos
Kaloy Katalin
Kovacs Eniko Nee Sandor
Somfai Eva
Chinoin Gyogyszer - Es Vegyeszeti Termekek Gyara R.t.
Fetherstonhaugh & Co.
Jaray Miklos
Kaloy Katalin
Kovacs Eniko Nee Sandor
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