Insulin crystals for pulmonary administration

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/62 (2006.01) A61K 9/00 (2006.01) A61K 38/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2370302

The invention relates to crystals comprising derivatized insulin or derivatized insulin analog, to processes for preparing such crystals, and to methods of treating diabetes comprising administering the crystals to a patient in need thereof to control blood glucose. Crystals having a desired mean size are obtained. The mean crystal size may be controlled so that the crystals may be administered advantageously by inhalation through the mouth, deposited in the deep lung, and absorbed there over a protracted period of time, to provide control of blood glucose between meals and overnight.

La présente invention concerne des cristaux contenant un dérivé d'insuline ou un dérivé d'analogue d'insuline, des procédés de préparation de tels cristaux, ainsi que des procédés de traitement de diabètes qui consistent à administrer les cristaux à des patients diabétiques afin de réguler leur glucose sanguin. Elle permet aussi d'obtenir des cristaux de taille recherchée. Il est possible d'agir sur la taille des cristaux de manière à ce qu'ils puissent être avantageusement inhalés via la bouche, déposés dans le poumon en profondeur, et absorbés sur une durée prolongée afin de permettre une régulation du glucose sanguin entre les repas et durant la nuit.

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