Insulin molecule having protracted time action

Details Insulin molecule having protracted time action Insulin molecule having protracted time action

C - Chemistry, Metallurgy

07

K

C07K 14/62 (2006.01) A61K 38/28 (2006.01) A61P 3/10 (2006.01) C07K 1/06 (2006.01) C30B 29/58 (2006.01)

Patent

CA 2468100

The present invention provides an insulin molecule that provides a protracted, even basal duration of action. The insulin molecule comprises a modification at the N-terminus of the A-chain, optionally a modification at the N-terminus of the B-chain, a modification at a B-chain lysine, and optionally a modification at the C-terminus of the A-chain. The present invention also provides a method of treating diabetes mellitus comprising administering the insulin molecule.

L'invention concerne une molécule d'insuline permettant de prolonger une durée d'action, même basale. Ladite molécule d'insuline comprend une modification sur la terminaison N de la chaîne A, éventuellement une modification sur la terminaison N de la chaîne B, une modification sur la lysine de la chaîne B, et éventuellement une modification sur la terminaison C de la chaîne A. L'invention concerne une méthode de traitement du diabète sucré comprenant l'administration de ladite molécule d'insuline.

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