Insulinotropic peptide derivative wherein its n-terminal...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/65 (2006.01)

Patent

CA 2693154

The present invention relates to an N-terminal amino acid-modified insulinotropic peptide having a high activity, and to a pharmaceutical composition comprising the same. The insulinotropic peptide derivatives according to the present invention exhibit therapeutic effects, which are not observed in native and other insulinotropic peptide analogs. Therefore, the insulinotropic peptide derivatives and the pharmaceutical composition comprising the same according to the present invention can be effectively provided for the treatment of the diseases.

L'invention concerne un peptide insulinotropique à acide aminé N-terminal modifié présentant une activité élevée, ainsi qu'une composition pharmaceutique le contenant. Les dérivés de peptide insulinotropique selon l'invention présentent des effets thérapeutiques qui ne sont pas observés dans des analogues de peptide insulinotropique natifs ou autres. Les dérivés de peptide insulinotropique et la composition pharmaceutique les contenant peuvent être utilisés efficacement dans le traitement de certaines maladies.

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