Interdigitation-fusion liposomes and gels

Details Interdigitation-fusion liposomes and gels Interdigitation-fusion liposomes and gels

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 49/00 (2006.01) A61L 2/00 (2006.01) A61L 2/02 (2006.01)

Patent

CA 2146115

This invention relates to interdigitation-fusion (IF) liposomes and gels. These liposomes and gels capture high solute to lipid ratios, including bioactive agent. This invention also relates to the discovery that the fusion of liposomes to produce IF gel and liposomes according to the present invention is size dependent. The present in- vention also relates to a method for producing IF lipo- somes and gels. In the method of the present invention, sized liposomes formed by sonication, extrusion or altern- ative processes are fused in the presence of ethanol or other suitable inducer. This process results in a composi- tion of the present invention in gel form. To produce lipo- somes, the gels are exposed to a temperature usually but not necessarily above the transition temperature (Tm) of the lipid used. The temperature required by the methods of the invention is that temperature which induces a change in the material properties of the mixture. The in- ducer may also be removed. The result is a composition comprising liposomes containing high solute to lipid ra- tios. The IF liposomes and gels of the present invention may be used in combination with numerous solutes, espe- cially including bioactive agents.

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