C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) C07K 1/22 (2006.01) C07K 14/435 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C12N 1/21 (2006.01) C12N 5/18 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2162353
A polypeptide which has a molecular weight of 18,500~3,000 daltons on SDS-PAGE and a pI of 4.9~1.0 on chromatofocusing. The polypeptide strongly induces the IFN-.gamma. production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose. It is readily prepared by using a monoclonal antibody obtained from hybridomas, and incorporated into agents for treating and/or preventing malignant tumors, viral diseases, bacterial infectious diseases, and immune diseases.
L'invention porte sur un polypeptide ayant un poids moléculaire de 18 500 à 3 000 daltons en SDS-PAGE et un pI de 4,9 à 1,0 en chromatofocalisation. Le polypeptide induit fortement la production d'IFN-gamma des cellules immunocompétentes, même en petite quantité. Son administration ne cause pas d'effets indésirables graves chez l'humain, même aux doses relativement élevées. On le produit facilement à l'aide d'anticorps monoclonaux obtenus d'hybridomes. On l'ajoute aux agents destinés au traitement et/ou au traitement préventif des cancers, des maladies virales, des maladies infectieuses bactériennes et des maladies immunitaires.
Fukuda Shigeharu
Kohno Keizo
Kunikata Toshio
Kurimoto Masashi
Okamura Haruki
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
Macrae & Co.
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