Interleukin-9 and interleukin-4 chimeric antagonist muteins...

Details Interleukin-9 and interleukin-4 chimeric antagonist muteins... Interleukin-9 and interleukin-4 chimeric antagonist muteins...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C07K 14/54 (2006.01) C12P 21/04 (2006.01)

Patent

CA 2581469

Chimeric polypeptide antagonists that include an interleukin-4 (IL-4) mutein linked to an interleukin-9 (IL-9) mutein are provided, as are polynucleotides encoding the IL-4 and IL~9 chimeric mutein antagonists. Also provided are methods of using the chimeric mutein antagonists and encoding polypeptides to reduce or inhibit the responsiveness of a cell to a cytokine such as IL-4, IL- 9 and/or interleukin-13. Methods using the compositions to treat disorders such as pulmonary disorders (e.g., asthma) also are provided.

L'invention concerne des polypeptides antagonistes chimères qui comportent une mutéine d'interleukine-4 (IL-4) liée à une mutéine d'interleukine-9 (IL-9), ainsi que des polynucléotides codant les antagonistes chimères vis-à-vis de ces mutéines. On décrit également des procédés d'utilisation des antagonistes en question et de codage de ces polypeptides pour réduire ou inhiber la réactivité d'une cellule à une cytokine du type IL-4, IL-9 et/ou interleukine-13. On décrit enfin des procédés d'utilisation des compositions considérées pour traiter des troubles commes les maladies pulmonaires (par exemple, asthme).

Affiliated with

Also associated with

Rating

Interleukin-9 and interleukin-4 chimeric antagonist muteins... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Interleukin-9 and interleukin-4 chimeric antagonist muteins..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Interleukin-9 and interleukin-4 chimeric antagonist muteins... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1753791