C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 305/14 (2006.01) C07C 233/87 (2006.01) C07D 263/16 (2006.01) C07D 303/48 (2006.01) C07D 407/12 (2006.01) C07D 413/12 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01) C07F 7/30 (2006.01)
Patent
CA 2236293
The present invention relates to new intermediaries for the hemisynthesis of taxanes and their preparation processes. It relates particularly to derivatives of oxazolidines or oxazolidinones, as well as to new derivatives of baccatine III. The general process for the synthesis of taxanes according to the invention enables to obtain a product such as PACLITAXEL<TM> in only five steps from products available in the market, compared to nine steps in general, for processes of the prior art.
La présente invention concerne de nouveaux intermédiaires pour l'hémisynthèse de taxanes et leurs procédés de préparation. Il s'agit notamment de dérivés d'oxazolidines ou d'oxazolidinones, ainsi que de nouveaux dérivés de la baccatine III. Le procédé général de synthèse des taxanes selon l'invention permet d'obtenir un produit tel que le PACLITAXEL.TM. en seulement cinq étapes à partir de produits disponibles dans le commerce, contre généralement neuf étapes pour les procédés de l'état de la technique.
Chanteloup Luc
Chauveau Bruno
Corbin Christine
Dhal Robert
Lamy Arnaud
Robic
Societe D'etude Et de Recherche En Ingenierie Pharmaceutique Ser
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