Isolated nucleic acid sequence coding for a tumor rejection...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/74 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2194451

The invention relates to nucleic acid molecules coding for a tumor rejection antigen precursor. Specifically, the tumor rejection antigen precursor, or "TRAP", is processed into at least one tumor rejection antigen, which is presented by HLA-A2 molecules. Ramifications of the discovery are also set forth.

L'invention porte sur des molécules d'acide nucléique codant pour le précurseur d'un antigène de rejet des tumeurs (TRAP) lequel est spécifiquement élaboré pour former au moins un antigène de rejet des tumeurs présenté par les molécules des antigènes leucocytaires humains (HLA-A2). Elle porte également sur les implications de cette découverte.

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