Isolated peptides derived from mage tumor rejection antigen...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/705 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/74 (2006.01) C12N 5/10 (2006.01) G01N 33/574 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2186004

Tumor rejection antigens derived from MAGE tumor rejection precursors have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.

Des antigènes de rejet des tumeurs dérivant de précurseurs de l'antigène MAGE de rejet des tumeurs ont été identifiés. Ces antigènes de rejet des tumeurs (TRAS) se fixent à la molécule d'HLA-A2 de la classe I de la CMH, et le complexe résultant stimule la production de clones de cellules T cytolytiques qui lysent les cellules apparaissant. Ces peptides et ces complexes peuvent servir à des fins de diagnostic et de traitement, ou d'immunogènes pour la production d'anticorps, ou de cibles pour la production de clones de cellules T cytolytiques.

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