Isolated peptides which bind to hla-b35 molecules

Details Isolated peptides which bind to hla-b35 molecules Isolated peptides which bind to hla-b35 molecules

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) C07K 14/74 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2326675

The invention relates to peptides which bind to HLA-B35 molecules, leading to recognition and lysis of the resulting complexes by cytolytic T cells. Also a part of the invention are nucleic acid molecules which encode these peptides, and uses of each of these. The molecules are derived, in some cases, from tyrosinase, and portions of the tyrosinase molecule and portions of nucleic acid molecules which encode tyrosinase are also a part of the invention.

L'invention porte sur des peptides se fixant aux molécules HLA-B35, ce qui conduit à la reconnaissance et à la lyse des complexes résultants par les cellules T cytolytiques. L'invention porte également sur des molécules d'acide nucléique codant pour ces peptides et sur l'utilisation de chacun d'eux, lesdites molécules pouvant dériver dans certains cas de la tyrosinase. L'invention porte en outre sur des fractions de molécules de tyrosinase et des fractions de molécules d'acide nucléique codant pour la tyrosinase.

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