Isolation of a novel senescence-factor gene, p23

Details Isolation of a novel senescence-factor gene, p23 Isolation of a novel senescence-factor gene, p23

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2296598

Provided are an isolated senescence-related nucleic acid molecule encoding a 23 kilodalton polypeptide (p23), methods for expressing the 23 kilodalton polypeptide in cultured cells, recombinant p23 polypeptides, expression vectors and host cells expressing p23, and antibodies against p23. Also provided are methods for using p23 to modulate senescence, and for determining p23 expression in biological samples.

L'invention concerne une molécule isolée d'acide nucléique relative à la sénescence codant un polypeptide de 23 kilodaltons (p23), des procédés servant à exprimer ce polypeptide de 23 kilodaltons dans des cultures de cellules, des polypeptides p23 de recombinaison, des vecteurs d'expression et des cellules hôtes exprimant p23, ainsi que des anticorps contre p23. Elle concerne également des procédés permettant de mettre en application p23 afin de moduler la sénescence, et de déterminer l'expression de p23 dans des spécimens biologiques.

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