Isoquinoline derivatives

Details Isoquinoline derivatives Isoquinoline derivatives

C - Chemistry, Metallurgy

07

D

167/227, 260/271

C07D 471/00 (2006.01) A61K 31/475 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01)

Patent

CA 1268178

Abstract Summary ISOQUINOLINE DERIVATIVES Pharmaceutical compositions for combatting cancer comprising a compound of formula (I) Image (I) (wherein R1 represents a hydrogen atom or a C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl group; R2 represents a hydrogen atom or a hydroxyl, C1-4 alkoxy or C2-4 alkanoyloxy group; R3 represent a hydrogen atom, or (when R2 is other than a hydrogen atom) optionally a hydroxyl, C1-4 alkoxy or C2-4 alkanoyloxy group, or R2 and R3 together represent a methylenedioxy group; R4 represents a hydrogen or halogen atom or a C1- 3/alkyl group or a phenyl group optionally substituted by a halogen atom or a hydroxy, C1-4 alkyl, C1-4 alkoxy or C1-4 alkanoyloxy group; and the ring A represents a group of formula (i) Image (ii) Image or (iii) Image where R5 and R6 each represent a hydrogen atom or a hydroxyl, C1-4 alkoxy or C1-4 alkanoyloxy group, R and R each represents a hydrogen atom or a methyl group, and one of X, X1, X2 and X3 represents a nitrogen atom and the others represent -CH- groups; with the proviso that where A represents a group of formula (i) at least one of R1 to R6 represents other than a hydrogen atom) together with at least one pharmaceutical carrier or excipient.

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