Isoxazole-.beta.-carboline derivatives

Details Isoxazole-.beta.-carboline derivatives Isoxazole-.beta.-carboline derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/276

C07D 471/04 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1324382

(1) Abstract of the Disclosure B-Carbolines of general Formula I Image I, wherein Y represents the residue Image or Image and Ra and Rb, being identical or different, mean respectively hydrogen, C1-6-alkoxy, phenyl, C3-7-cyclo alkyl, optionally substituted C1-6-alkyl or C1-6-alkoxycarbonyl, and Rc and Rd, being identical or different, mean respectively hydrogen or C1-6-alkyl or jointly a linkage, and R4 is hydrogen, C1-6-alkyl or C1-6-alkoxy-C1-6-alkyl and R5 is hydrogen, halogen, OR6, NR7R8 or CH R9R10 wherein R6 means C1-6-alkyl, C3-7-cycloalkyl or an optionally substituted aralkyl, aryl or hetaryl residue, R7 and R8, being identical or different, (2) represent hydrogen, C1-6-alkyl, C3-6-alkenyl, or jointly with the nitrogen atom a saturated heterocyclic five- or six-membered ring which optionally contains a further hetero atom, R9 means hydrogen or C1-6-alkyl, R10 means hydrogen, C1-6-alkyl, OR11 or NR12R13 wherein R11 means C1-6-alkyl, R12 and R13 are identical or different and mean hydrogen, C1-6-alkyl or jointly with the nitrogen atom a saturated heterocyclic five- or six-membered ring optionally containing a further hetero atom provided that when R5 and R4 are hydrogen, Y is other than 3-methyl-isoxazol-5-yl, and useful to treat epilepsy or anxiety.

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