Isoxazoline, isothiazoline and pyrazoline factor xa inhibitors

Details Isoxazoline, isothiazoline and pyrazoline factor xa inhibitors Isoxazoline, isothiazoline and pyrazoline factor xa inhibitors

C - Chemistry, Metallurgy

07

D

C07D 261/04 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 231/06 (2006.01) C07D 275/02 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01) C07D 487/10 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01) C07D 498/10 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2240946

Isoxazolines,isothiazolines and pyrazolines which are inhibitors of Factor Xa, pharmaceutical compositions containing these compounds,and (see fig.I) methods of using these compounds as anticoagulant agents for treatment and prevention of thromboembolic disorders. The compounds can be represented by formula (I) where X is 0, S or NR15.

L'invention porte sur des isoxazolines, des isothiazolines ainsi que des pyrazolines, inhibiteurs du facteur Xa, sur des compositions pharmaceutiques renfermant ces composés, ainsi que sur des méthodes d'utilisation (voir fig. I) de ces composés comme agents anticoagulants pour le traitement et la prévention de troubles thrombo-emboliques. Ces composés peuvent être représentés par la formule (I) dans laquelle X représente O, S ou NR15.

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