K-ras mutations and anti-egfr antibody therapy

Details K-ras mutations and anti-egfr antibody therapy K-ras mutations and anti-egfr antibody therapy

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2680326

The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors.

Cette invention se rapporte à des mutations de KRAS, à des polynucléotides codant des polypeptides KRAS mutants et à des procédés d'identification des mutations de KRAS. Cette invention concerne également des procédés permettant de diagnostiquer le cancer, ainsi que des procédés et des kits permettant de prédire l'utilité d'agents de fixation spécifiques anti-EGFR dans le traitement des tumeurs.

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