Kappa/mu-like protein tyrosine phosphatase, ptp lambda

Details Kappa/mu-like protein tyrosine phosphatase, ptp lambda Kappa/mu-like protein tyrosine phosphatase, ptp lambda

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 5/16 (2006.01) C12N 9/16 (2006.01) C12N 15/12 (2006.01) C12Q 1/42 (2006.01)

Patent

CA 2253431

This invention concerns novel receptor protein tyrosine phosphatase polypeptides. Specifically, this invention concerns the novel receptor protein tyrosine phosphatase .lambda. which is related to the homotypically adhering receptor protein tyrosine phosphatases and µ. The invention further relates to analogs of these polypeptides in other mammals, functional derivatives thereof, antibodies which are capable of specifically binding to these polypeptides, nucleic acids encoding these polypeptides, vectors containing and capable of expressing such nucleic acid and recombinant host cells transformed with such nucleic acid. Methods for the recombinant production of these receptor protein tyrosine phosphatase polypeptides and assays for identifying agonists and antagonists of these polypeptides are also within the scope of the invention.

L'invention porte sur de nouveaux polypeptides humains du type protéine tyrosine phosphatase réceptrice, et spécifiquement sur la nouvelle protéine tyrosine phosphatase réceptrice .lambda. parente des protéines tyrosine phosphatases réceptrices ? et µ d'adhérence homotypique. L'invention porte également sur des analogues de ces polypeptides présents chez d'autres mammifères, sur leurs dérivés fonctionnels, sur des anticorps se fixant spécifiquement à ces polypeptides, sur des vecteurs contenant de tels acides nucléiques et capables de les exprimer, et sur des cellules hôtes de recombinaison transformées à l'aide desdits acides nucléiques. L'invention porte en outre sur la production par recombinaison de ces polypeptides du type protéine tyrosine phosphatase réceptrice et sur des essais d'identification des agonistes et antagonistes desdits polypeptides.

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