Kappa-opiate agonists for inflammatory bowel disorders

Details Kappa-opiate agonists for inflammatory bowel disorders Kappa-opiate agonists for inflammatory bowel disorders

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2179955

The invention relates to pharmaceutical prepara- tions which are suitable for the treatment of inflamma- tory bowel disorders and contain at least one compound of the formula I Image in which R is Ar, cycloalkyl having 3-7 C atoms or cyclo- alkylalkyl having 4-8 C atoms, R 2 is Ar, R1 and R2 together are also Image R3 is H, OH, OA or A, R4 is A or phenyl which can optionally be mono- or disubstituted by Hal, OH, OA, CF3, NO2, NH2, NHA, NRCOA, NHSO2A or NA2, R5 is OH, CH2OH, R6 and R7 in each case independently of one another are H, Hal, OH, OA, CF3, NH2, NHA, NA2, NHCOA, NHCONH2, NO2 or methylenedioxy, A is alkyl having 1-7 C atoms, Ar is a mono- or bicyclic aromatic-radical which can optionally contain an N, O or S atom and can be mono-, di- or trisubstituted by A, Hal, OH, OA, CF31 NH2, NHA, NA2, NHCOA and/or NHCONH2, D is CH2, O, S, NH, NA, -CH2-CH2-, -CH=CH-, -CH2NH-, -CH2-NA- or a bond and Hal is F, Cl, Br or I, and/or one of its physiologically acceptable salts and/or one of its glycosylated derivatives, and at least one physiologically acceptable excipient or auxiliary.

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