Kdel receptor inhibitors

Details Kdel receptor inhibitors Kdel receptor inhibitors

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/78 (2006.01) C12N 15/52 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2337692

The present invention relates to inhibitors of the KDEL receptor and therapeutic uses therefor. Certain proteins are functionally retained in the cellular endoplasmic reticulum via an interaction between a KDEL sequence and its receptor. According to the invention, blocking this interaction with a KDEL receptor inhibitor poromotes the secretion of such proteins. In specific embodiments of the invention, KDEL receptor inhibitors may be used to promote the secretion of heat shock proteins, thereby rendering the secreted heat shock proteins more accessible to the immune system and improving the immune response to heat shock protein-associated antigens.

L'invention concerne des inhibiteurs des récepteurs de KDEL et l'utilisation de méthodes thérapeutiques correspondantes. Certaines protéines sont fonctionnellement retenues dans le réticulum endoplasmique cellulaire via une interaction d'une séquence KDEL et de son récepteur. Selon l'invention, le blocage de l'interaction avec un inhibiteur des récepteurs de KDEL stimule la sécrétion de ces protéines. Dans des modes de réalisation spécifiques, les inhibiteurs des récepteurs de KDEL peuvent servir à stimuler la sécrétion de protéines de choc thermique plus accessibles par le système immunitaire et qui améliorent la réaction immunitaire aux antigènes associés aux protéines de choc thermique.

Affiliated with

Also associated with

Rating

Kdel receptor inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Kdel receptor inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Kdel receptor inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1957834