Kdr and vegf/kdr binding peptides and their use in diagnosis...

Details Kdr and vegf/kdr binding peptides and their use in diagnosis... Kdr and vegf/kdr binding peptides and their use in diagnosis...

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 47/48 (2006.01) A61K 49/06 (2006.01) A61K 49/22 (2006.01) A61K 51/00 (2006.01) A61K 51/08 (2006.01) C07K 7/06 (2006.01) C07K 14/00 (2006.01) C07K 14/52 (2006.01) C07K 14/71 (2006.01) C07K 19/00 (2006.01) C12N 7/01 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2477836

The present invention provides binding polypetides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, Detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 ~M).

L'invention concerne des polypeptides liants pour le complexe KDR ou VEGF/KDR, qui peuvent être utilisés de façon variée à chaque fois qu'il avantageux de traiter, détecter, isoler ou localiser une angiogenèse. Elle concerne, en particulier, des polypeptides synthétiques, isolés, pouvant se lier au complexe KDR ou VEGF/KDR avec une grande affinité (c'est à dire avec un K<SB>D</SB><1 ?M).

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