Kdr and vegf/kdr binding peptides and their use in diagnosis...

Details Kdr and vegf/kdr binding peptides and their use in diagnosis... Kdr and vegf/kdr binding peptides and their use in diagnosis...

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) A61P 35/00 (2006.01) C07K 7/64 (2006.01) C12N 7/02 (2006.01) C12N 15/63 (2006.01) C12Q 1/00 (2006.01) C12Q 1/70 (2006.01) C40B 30/04 (2006.01) G01N 33/52 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2513044

The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEFG/KDR complex with high affinity (e.g., having a KD < 1 µM), and dimer and multimeric constructs comprising these polypeptides.

La présente invention concerne des polypeptides, des complexes peptidiques dimères et multimères comprenant au moins une fraction de liaison pour complexe KDR ou VEGF/KDR, qui se prêtent à des utilisations diverses dans les cas où il est bon de traiter, détecter, isoler ou localiser un angiogenèse. L'invention concerne en particulier des polypeptides synthétiques isolés capables d'une grande affinité de liaison pour un complexe KDR ou VEFG/KDR (ayant notamment un K<SB>D</SB> < 1 ?M), ainsi que des constructions dimères ou multimères renfermant ces polypeptides.

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