Kynurenic acid amide derivatives as nr2b receptor antagonists

Details Kynurenic acid amide derivatives as nr2b receptor antagonists Kynurenic acid amide derivatives as nr2b receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4709 (2006.01) A61P 25/04 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2574167

The new kynurenic acid amide derivatives of formula (I): and optical antipodes, racemates and the salts thereof are highly effective and selective antagonists of NMDA receptor, and moreover most of the compounds are selective antagonist of NR2B subtype of NMDA receptor.

L'invention concerne de nouveaux dérivés amides d'acide kynurénique correspondant à la formule (I) et leurs antipodes optiques, racémates et sels, qui sont hautement efficaces en tant qu'antagonistes sélectifs du récepteur NMDA; en outre, la plupart des composés sont des antagonistes sélectifs du sous-type NR2B du récepteur NMDA.

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