C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 51/08 (2006.01)
Patent
CA 2016235
The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, or therapeutically-conjugated, chemotactic peptide which accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structure N - X - Y - Leu - Phe - Z - W Where: X = Formyl for agonists - A more bulky group such as t - Boc for antagonist. Y = Met or Nle. Z*= is a spacer sequence such as Gly - Gly - Gly W*= is a labeling or attachment substituent, i.e., N-epsilon (DTPA) Lys - putrescine for labeling. - OSU (S03) for attachment to a high molecular weight carrier *At the Z and W positions either D or L amino acids can be used.
Fischman Alan J.
Fuccello Anthony J.
Kroon Daniel J.
Riexinger Douglas J.
Rubin Robert H.
Gowling Lafleur Henderson Llp
Ortho Pharmaceutical Corporation
The General Hospital Corporation
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