C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/20 (2006.01) A61K 31/438 (2006.01)
Patent
CA 2585797
The present invention relates to inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-.beta. hydroxyl steroid dehydrogenase type 1and/or diseases associated with aldosterone excess.
L'invention concerne des inhibiteurs de déshydrogénase stéroïde hydroxyle 11-ß de type 1, des antagonistes du récepteur minéralocorticoïde (MR), et des compositions de ceux-ci. Les composés de l'invention peuvent être utiles pour traiter des maladies variées associées à l'expression ou à l'activité de la déshydrogénase stéroïde hydroxyle 11-ß de type 1 et/ou des maladies associées à un excès d'aldostérone.
Burns David M.
He Chunhong
Metcalf Brian W.
Qian Ding-Quan
Xu Meizhong
Incyte Corporation
Smart & Biggar
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