Large comb-type branched polynucleotides

Details Large comb-type branched polynucleotides Large comb-type branched polynucleotides

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 19/06 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2087961

2087961 9202526 PCTABS00010 Comb-type branched polynucleotides of formula (I) are used as amplification multimers in nucleic acid hybridization assays, where S is a first spacer segment of at least about 15 nucleotides, X is a modified nucleotide that provides a branch site, S' is a branching site spacer segment of 0 to about 15 nucleotides, m is an integer equal to or greater than 15, R is a cleavable linker molecule, n is 0 or 1, S'' is a second spacer segment of about 0 to 10 nucleotides, A is a segment that is capable of hybridizing specifically to analyte nucleic acid or nucleic acid bound to analyte, S''' is a third spacer segment of 0 to 10, E is an oligonucleotide extension of 5 to 10 nucleotides, and L is a segment containing 2 to 10 iterations, of a sequence that is capable of hybridizing specifically to a labeled oligonucleotide probe.

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