Carbacephem .beta.-lactam antibiotics

Details Carbacephem .beta.-lactam antibiotics Carbacephem .beta.-lactam antibiotics

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4353 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2701286

Carbacephem .beta.-lactam antibiotics having the following chemical structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar , R1, R2 and R3 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.

Cette invention se rapporte à des antibiotiques bêta-lactames à carbacéphème de structures chimiques (I) et (II) suivantes, y compris leurs stéréo-isomères, sels pharmaceutiquement acceptables, esters et promédicaments, où Ar2, R1, R2 et R3 sont tels que définis ici. Les composés sont utilisés dans le traitement des infections bactériennes, en particulier celles causées par Staphylococcus spp résistant à la méthicilline.

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