C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61P 1/00 (2006.01) C07H 21/04 (2006.01) C07K 14/195 (2006.01) C07K 14/205 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2372098
The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis which encodes an immunogenic FlgE peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.
La présente invention concerne d'une façon générale des compositions thérapeutiques destinées au traitement et/ou à la prophylaxie des maladies intestinales chez les animaux et les oiseaux causées ou aggravées par Lawsonia intracellularis ou par des micro-organismes similaires ou apparentés. Cette invention concerne en particulier un gène dérivé de Lawsonia intracellularis codant pour un peptide immunogène FlgE, un polypeptide ou une protéine qui convient particulièrement comme antigène dans une préparation de vaccin destiné à apporter une immunité humorale contre Lawsonia intracellularis et les micro-organismes pathogènes des animaux. La présente invention concerne aussi des méthodes destinées au traitement et à la prophylaxie de ces maladies intestinales, des agents diagnostiques et des méthodes permettant de détecter Lawsonia intracellularis ou des micro-organismes similaires ou apparentés.
Ankenbauer Robert Gerard
Hasse Detlef
Panaccio Michael
Parsons Jim
Rosey Everett Lee
Agriculture Victoria Services Pty Ltd
Australian Pork Limited
Pfizer Products Inc.
Smart & Biggar
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