Lces as modifiers of the p53 pathway and methods of use

Details Lces as modifiers of the p53 pathway and methods of use Lces as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C12P 21/06 (2006.01) C12Q 1/527 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2448112

Human LCE genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of LCE are provided.

L'invention concerne des gènes humains LCE identifiés comme étant des modulateurs de la voie p53 et, par conséquent, des cibles thérapeutiques pour des troubles associés à une fonction défectueuse de p53. L'invention concerne également des procédés d'identification de modulateurs de p53 consistant à effectuer un criblage d'agents modulant l'activité des LCE.

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