Lipase variant

Details Lipase variant Lipase variant

C - Chemistry, Metallurgy

12

N

C12N 9/20 (2006.01) C11D 3/386 (2006.01)

Patent

CA 2366843

Certain variants of Lipolase (wild-type Humicolalanuginosa lipase) have a particularly good first-wash performance in a detergent solution. The variants should comprise one or more substitutions with positive amino acids near the N- terminal in the three-dimensional structure. The variants should further comprise a peptide addition at the C-terminal and/or should meet certain limitations on electrically charged amino acids at positions 90-101 and 210.

Certaines variantes génétiques de Lipolase (Humicolalanuginosa lipase de type sauvage) présentent des performances particulièrement bonnes de premier lavage dans une solution de détergent. Ces variantes génétiques doivent comporter une ou plusieurs substitutions d'acides aminés positifs à proximité de l'extrémité N-terminale de la structure tridimensionnelle. Les variantes génétiques comportent en outre une adjonction de peptide à l'extrémité C-terminale et/ou doivent présenter certaines limitations concernant les acides aminés chargés aux positions 90-101 et 210.

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