Lipid glycerides for the treatment of neurodegenerative...

Details Lipid glycerides for the treatment of neurodegenerative... Lipid glycerides for the treatment of neurodegenerative...

C - Chemistry, Metallurgy

07

C

C07C 69/587 (2006.01) A61K 31/232 (2006.01) A61P 25/28 (2006.01) C07C 67/14 (2006.01)

Patent

CA 2534202

A method is provided for treating a patient in need of therapy for a neurodegenerative disease comprising administering to that patient a therapeutically effective dose of a lipid glyceride comprising a glycerol moiety and a fatty acid moiety, the fatty acid moiety being selected from the group consisting of .gamma.-linolenic acid, dihomo-.gamma.-linolenic acid and arachidonic acid characterised in that the selected fatty acid moiety is attached to the glycerol moiety at its sn-2 position. Preferably the method is that wherein the lipid is administered for a duration and at a dose sufficient to maintain or elevate TGF-.beta.1 levels in the patient to therapeutic levels.

L'invention concerne un procédé permettant de traiter un patient nécessitant un traitement contre une maladie neurodégénérative, consistant à administrer à ce patient une dose thérapeutiquement efficace d'un glycéride lipidique comprenant une fraction glycérol et une fraction acide gras, ladite fraction acide gras étant sélectionnée dans le groupe qui comprend les acides .gamma.-linolénique, dihomo-.gamma.-linolénique et arachidonique. Cette invention est caractérisée en ce que la fraction acide gras sélectionnée est liée à la fraction glycérol au niveau de sa position sn-2. De préférence, le procédé selon l'invention consiste à administrer le lipide pendant une durée et à une dose qui suffisent à maintenir ou augmenter les taux de TGF-.beta.1 du patient à des taux thérapeutiques.

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