Liposomal composition comprising an active ingredient for...

A - Human Necessities – 61 – K

Patent

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A61K 9/127 (2006.01)

Patent

CA 2583332

The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.

La présente invention concerne une composition pharmaceutique à base d'un principe actif pour application topique encapsulé dans des liposomes, à l'intérieur desquels est renfermé un milieu aqueux, dans lequel est contenu au moins un principe actif, exerçant directement ou indirectement un effet relaxant sur la musculature lisse et sélectionné, de préférence, dans le groupe des prostaglandines, des adénylcyclases, des cAMP, AMP, ATP, des NO synthétases, des monoxydes d'azote (NO), des composés NO, des nitrates, des guanylcyclases, des cGMP, GMP, GTP et des phosphodiesterases, en particulier le sildénafil. Cette invention concerne également un procédé pour produire cette composition, éventuellement sous forme stérile, ainsi que l'utilisation des liposomes chargés de principe actif dans différentes formulations galéniques pour application externe dans la zone génitale, pour la prophylaxie et/ou la thérapie de troubles sexuels chez l'homme et la femme et/ou pour augmenter la sensation sexuelle.

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