Liposomal formulation of clobetasol propionate

Details Liposomal formulation of clobetasol propionate Liposomal formulation of clobetasol propionate

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2416731

The invention relates to a formulation of clobetasol propionate for topical use in the treatment of skin diseases such as atopic dermatitis and psoriasis. Said formulation has an excellent organoleptic appearance, very good therapeutic effect and favorable distribution in the stratum corneum. The liposomes include clobetasol propionate as active substance in low dose. Said liposomes are preferably stable and multilamellar vesicles, with an average size of 2000-5000 nm. The amount of active substance is preferably between 0.02 and 0.025 %. The pharmaceutical form of the product is preferably a jelly.

L'invention concerne une formulation de propionate de clobétasol à usage topique pour le traitement de maladies de la peau, telles que la dermatite atopique et le psoriasis. Cette formulation présente un remarquable aspect organoleptique, un très bon effet thérapeutique et une bonne distribution dans la couche cornée. Les liposomes comprennent du propionate de clobétasol comme principe actif à faible dose. Ces liposomes sont de préférence des vésicules stables et multilamellaires présentant un dimension moyenne de 2000-5000 nm. La quantité de principe actif est comprise de préférence entre 0,02 et 0,025 %. Ce produit se présente de préférence sous la forme pharmaceutique de gelée.

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