Liquid preparation

Details Liquid preparation Liquid preparation

A - Human Necessities

61

K

A61K 9/08 (2006.01) A61K 9/00 (2006.01) A61K 47/38 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2659390

It is provided a liquid preparation stably including (2S)-I- (4-amino-2, 3, 5-trimethylphenoxy) -3-{ 4-[ 4- (4-fluorobenzyl) phenyl] -1- piperazinyl} -2-propanol or its pharmaceutically acceptable salt as an active ingredient. The present invention relates to a liquid preparation including the above compound or its pharmaceutically acceptable salt as an active ingredient, the liquid preparation including: (a) at least one selected from the group consisting of sulfite, bisulfite, pyrosulfite, .alpha.-thioglycerol and cysteine, (b) a .beta.-cyclodextrin derivative, and (c) a pH buffer, wherein the pH value thereof is adjusted within a range of from 3 to 5.

Cette invention concerne une préparation liquide qui comprend, de manière stable, (2S)-I- (4-amino-2, 3, 5-trimethylphenoxy) -3-{ 4-[ 4- (4-fluorobenzyl) phenyl] -1- piperazinyl} -2-propanol ou ses sels pharmaceutiquement acceptables en tant que principe actif. Cette inventio concerne une préparation liquide contenant le composé susmentionné ou ses sels pharmaceutiquement acceptables en tant que principe actif. Cette préparation liquide comprend: (a) au moins un composant choisi dans le groupe comprenant le sulfite, le bisulfite, le pyrosulfite, l'.alpha.-thioglycerol et la cystéine, (b) un dérivé .beta.-cyclodextrine, et (c) un tampon pour pH, la valeur du pH étant comprise entre 3 et 5.

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