Lna antagonists targeting the androgen receptor

Details Lna antagonists targeting the androgen receptor Lna antagonists targeting the androgen receptor

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2705714

The present invention relates to oligomer compounds (oligomers), which target the androgen receptor mRNA in a cell, leading to reduced expression of the androgen receptor. Reduction of the androgen receptor expression is beneficial for the treatment of certain medical disorders, such as a disease or a medical disorder as disclosed herein, such as a hyperproliferative disorder, such as cancer.

La présente invention porte sur des composés oligomères (oligomères) qui ciblent l'ARNm du récepteur de l'androgène dans une cellule, conduisant à une expression réduite du récepteur de l'androgène. La réduction de l'expression du récepteur de l'androgène est utile pour le traitement de certains troubles médicaux, tels qu'une maladie ou un trouble médical tel que décrit ici, notamment une maladie hyperproliférative telle que le cancer.

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