Lo-cd2a antibody and uses thereof for inhibiting t cell...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/46 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2262546

The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of the LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.

L'invention a pour objet un anticorps LO-CD2a et des procédés d'utilisation d'anticorps ou de molécules de ce type, qui sont capables de se lier au même épitope (ou à une partie de cet épitope) pour empêcher et inhiber une réponse immunitaire chez des patients humains, de préférence. La réponse immunitaire est déclenchée par l'activation et la prolifération de cellules T ou de cellules tueuses naturelles. L'administration d'une quantité appropriée de l'anticorps LO-CD2a à un patient humain empêche ou inhibe le rejet d'une greffe, une réaction du greffon contre l'hôte ou une maladie auto-immune.

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