C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/06 (2006.01) A61K 31/66 (2006.01) A61P 17/02 (2006.01) A61P 35/00 (2006.01) C07F 9/09 (2006.01) C07F 9/11 (2006.01) C07F 9/17 (2006.01) C07F 9/22 (2006.01) C07F 9/38 (2006.01) C07F 9/40 (2006.01) C07F 9/6506 (2006.01) C07F 9/6571 (2006.01) C07F 9/6584 (2006.01)
Patent
CA 2402038
The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound. (see formula I)
La présente invention concerne des composés de formule (I) ainsi que des compositions pharmaceutiques contenant ces mêmes composés ; des procédés d'utilisation de ces composés qui présentent une activité en tant qu'agonistes ou qu'antagonistes des récepteurs de l'acide lysophosphatidique (LPA); ces procédés comprenant l'inhibition de l'activité LPA sur un récepteur LPA, la modulation de l'activité du récepteur LPA, le traitement du cancer, l'activation de la prolifération cellulaire et le traitement d'une blessure.
Baker Daniel L.
Dalton James T.
Elrod Don B.
Fischer David J.
Liliom Karoly
Smart & Biggar
The University Of Tennessee Research Corporation
University Of Tennessee Research Foundation
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