Lyophilized pharmaceutical compositions

A - Human Necessities – 61 – K

Patent

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A61K 9/19 (2006.01) A61K 31/4045 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01) A61K 47/40 (2006.01)

Patent

CA 2696914

Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, an chelator/antioxidant, a buffer or buffer component, and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus or iv infusion, or administered orally, e.g. as a drink solution.

L'invention porte sur des compositions pharmaceutiques qui comprennent un composé thérapeutique peu soluble dans l'eau, un solvant aqueux, un chélateur/antioxydant, un tampon ou composant de tampon et un agent diluant. Les compositions pharmaceutiques peuvent être ingérées par voie orale ou administrées par voie parentérale. Les compositions pharmaceutiques peuvent en outre être lyophilisées pour former un agglomérat pharmaceutiquement acceptable, lequel pourra être administré par voie orale, par exemple en tant que forme posologique orale solide ; ou bien reconstitué et administré par voie parentérale, par exemple sous forme de bolus intraveineux ou de perfusion intraveineuse unique, ou par voie orale, par exemple sous forme de solution buvable.

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