Macrocyclic analogs and methods of their use and preparation

Details Macrocyclic analogs and methods of their use and preparation Macrocyclic analogs and methods of their use and preparation

C - Chemistry, Metallurgy

07

D

C07D 493/22 (2006.01) A61K 31/357 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2335300

The invention provides halichondrin analogs having pharmaceutical activity, such as anticancer or antimitotic (mitosis-blocking) activity, and methods of identifying agents that induce a sustained mitotic block in a cell after transient exposure of the cell to the agents.

La présente invention concerne des analogues d'halichondrine ayant des propriétés pharmaceutiques, par exemple des propriétés anticancéreuses ou antimitotiques (blocage de la mitose), ainsi que des procédés d'identification d'agents produisant un blocage permanent de la mitose dans une cellule après une exposition transitoire de cette cellule aux agents précités.

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