Macrocyclic antagonists of the motilin receptor

Details Macrocyclic antagonists of the motilin receptor Macrocyclic antagonists of the motilin receptor

C - Chemistry, Metallurgy

07

K

C07K 5/12 (2006.01) A61K 38/06 (2006.01) A61K 38/12 (2006.01) C07K 1/113 (2006.01) C07K 5/08 (2006.01)

Patent

CA 2528375

The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.

Cette invention se rapporte à de nouveaux composés macrocycliques représentés par la formule (I) et à des sels, hydrates ou solvates de ceux-ci, acceptables sur le plan pharmaceutique, formule dans laquelle R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, n¿1?, m, p, Z¿1?, Z¿2? et Z¿3? sont tels que décrits dans les pièces descriptives de la demande. Cette invention concerne également des composés représentés par la formule (I) qui constituent des antagonistes du récepteur de motiline et qui sont utiles dans le traitement des affections associées à ce récepteur et/ou à un dysfonctionnement de la motilité.

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