Macrocyclic carboxylic acids and acylsulfonamides as...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2540858

The present invention provides compounds of the general formulas I-IX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The present invention further provides treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

L'invention concerne des composés représentés par les formules générales I à X, ainsi que des compositions, notamment des compositions pharmaceutiques, contenant un desdits composés. L'invention concerne également des méthodes de traitement, notamment des méthodes de traitement de l'infection par le virus de l'hépatite C et de la fibrose du foie. Ces méthodes consistent en général à administrer à un patient une quantité efficace d'un composé ou d'une composition selon l'invention.

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