C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/08 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) C07K 5/12 (2006.01)
Patent
CA 2699891
A class of macrocyclic compounds offormula (I), wherein R1, R3, R4, R a, R b, A, Z, Y, X, M, W,n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use ofsuch macrocyclic compounds for treating or preventing HCV infection. Formula (I):
L'invention concerne une catégorie de composés macrocycliques de formule (I), dans laquelle R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n et m sont tels que définis dans la description. Ces composés sont utiles en tant qu'inhibiteurs de protéases virales, en particulier de la protéase NS3 du virus de l'hépatite C (VHC). L'invention concerne également des procédés de synthèse et des méthodes d'utilisation de ces composés macrocycliques dans le traitement ou la prévention de l'infection par le VHC. Formule (I):
Butcher John
Di Filippo Marcello
Di Francesco Maria Emilia
Ferrara Marco
Harper Steven
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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