Macrocyclic compounds useful as bace inhibitors

Details Macrocyclic compounds useful as bace inhibitors Macrocyclic compounds useful as bace inhibitors

C - Chemistry, Metallurgy

07

D

C07D 498/18 (2006.01) A61K 31/395 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2593268

The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

L'invention concerne des composés macrocycliques de formule (I), dans laquelle toutes les variables sont telles que définies dans la spécification, le nombre d'atomes cycliques inclus dans l'anneau macrocyclique étant de 14, 15, 16 ou 17, sous forme de base libre ou de sel d'addition acide. La présente invention porte également sur leur préparation, sur leur utilisation en tant que médicaments et sur des médicaments les contenant.

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